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2023

Unit Publication
Shah A
Nguyen TAK
Petermann K
Khawaldeh S
Debove I
Shah SA
Torrecillos F
Tan H
Pogosyan A
Lachenmayer ML
Michelis J
Brown P
Pollo C
Krack P
Nowacki A
Tinkhauser G

Combining Multimodal Biomarkers to Guide Deep Brain Stimulation Programming in Parkinson Disease.

2023. Neuromodulation, 26(2):320-332.

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PMC7614142
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2.07 MB

2022

Unit Publication
Khawaldeh S
Tinkhauser G
Torrecillos F
He S
Foltynie T
Limousin P
Zrinzo L
Oswal A
Quinn AJ
Vidaurre D
Tan H
Litvak V
Kühn AA
Woolrich M
Brown P

Balance between competing spectral states in subthalamic nucleus is linked to motor impairment in Parkinson's disease.

2022. Brain, 145(1):237-250.

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PMC8967096
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1.33 MB

2021

Unit Publication
Duchet B
Ghezzi F
Weerasinghe G
Tinkhauser G
Kühn AA
Brown P
Bick C
Bogacz R

Average beta burst duration profiles provide a signature of dynamical changes between the ON and OFF medication states in Parkinson's disease.

2021. PLoS Comput Biol, 17(7)e1009116.

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PMC8263069
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4.04 MB
Unit Publication
Wiest C
Tinkhauser G
Pogosyan A
He S
Baig F
Morgante F
Mostofi A
Pereira EA
Tan H
Brown P
Torrecillos F

Subthalamic deep brain stimulation induces finely-tuned gamma oscillations in the absence of levodopa.

2021. Neurobiol Dis, 152:105287.

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PMC7116781
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10.76 MB

2020

Unit Publication
Muthuraman M
Bange M
Koirala N
Ciolac D
Pintea B
Glaser M
Tinkhauser G
Brown P
Deuschl G
Groppa S

Cross-frequency coupling between gamma oscillations and deep brain stimulation frequency in Parkinson's disease.

2020. Brain, 143(11):3393-3407.
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PMC7116448
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1.09 MB
Unit Publication
He S
Mostofi A
Syed EC
Torrecillos F
Tinkhauser G
Fischer P
Pogosyan A
Hasegawa H
Li Y
Ashkan K
Pereira EA
Brown P
Tan H

Subthalamic beta-targeted neurofeedback speeds up movement initiation but increases tremor in Parkinsonian patients.

2020. eLife, 9:e60979.
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PMC7695453
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1.9 MB
Unit Publication
Wiest C
Tinkhauser G
Pogosyan A
Bange M
Muthuraman M
Groppa S
Baig F
Mostofi A
Pereira EA
Tan H
Brown P
Torrecillos F

Local field potential activity dynamics in response to deep brain stimulation of the subthalamic nucleus in Parkinson's disease.

2020. Neurobiol. Dis., 143:105019.
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PMC7115855
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4.15 MB
Unit Publication
Yeh CH
Al-Fatly B
Kühn AA
Meidahl AC
Tinkhauser G
Tan H
Brown P

Waveform changes with the evolution of beta bursts in the human subthalamic nucleus.

2020. Clin. Neurophysiol., 131(9):2086-2099.
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PMC7115847
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1.62 MB
Unit Publication
Tinkhauser G
Torrecillos F
Pogosyan A
Mostofi A
Bange M
Fischer P
Tan H
Hasegawa H
Glaser M
Muthuraman M
Groppa S
Ashkan K
Pereira EA
Brown P

The Cumulative Effect of Transient Synchrony States on Motor Performance in Parkinson's Disease.

2020. J. Neurosci., 40(7):1571-1580.

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PMC7044725
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1.35 MB
Unit Publication
Khawaldeh S
Tinkhauser G
Shah SA
Petermann K
Debove I
Nguyen TAK
Nowacki A
Lachenmayer ML
Schuepbach M
Pollo C
Krack P
Woolrich M
Brown P

Subthalamic nucleus activity dynamics and limb movement prediction in Parkinson's disease.

2020. Brain, 143(2):582-596.
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PMC7009471
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1.1 MB

2019

Unit Publication
Chen CC
Yeh CH
Chan HL
Chang YJ
Tu PH
Yeh CH
Lu CS
Fischer P
Tinkhauser G
Tan H
Brown P

Subthalamic nucleus oscillations correlate with vulnerability to freezing of gait in patients with Parkinson's disease.

2019. Neurobiol. Dis., 132:104605.
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PMC6764839
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1.52 MB
Unit Publication
Meidahl AC
Moll CK
van Wijk B
Gulberti A
Tinkhauser G
Westphal M
Engel AK
Hamel W
Brown P
Sharott A

Synchronised spiking activity underlies phase amplitude coupling in the subthalamic nucleus of Parkinson's disease patients.

2019. Neurobiol. Dis., 127:101-113.
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PMC6545172
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2.71 MB

2018

Unit Publication
Moraud EM
Tinkhauser G
Agrawal M
Brown P
Bogacz R

Predicting beta bursts from local field potentials to improve closed-loop DBS paradigms in Parkinson’s patients

2018. Conf Proc IEEE Eng Med Biol Soc., 2018:3766-3769
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PMC6277014
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1.41 MB
Unit Publication
Torrecillos F
Tinkhauser G
Fischer P
Green AL
Aziz TZ
Foltynie T
Limousin P
Zrinzo L
Ashkan K
Brown P
Tan H

Modulation of Beta Bursts in the Subthalamic Nucleus Predicts Motor Performance.

2018. J. Neurosci., 38(41):8905-8917.
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PMC6181312
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1.29 MB
Unit Publication
Shah SA
Tan H
Tinkhauser G
Brown P

Towards Real-Time, Continuous Decoding of Gripping Force From Deep Brain Local Field Potentials.

2018.IEEE Trans Neural Syst Rehabil Eng, 26(7):1460-1468.
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PMC6044421
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1.13 MB
Unit Publication
Tinkhauser G
Torrecillos F
Duclos Y
Tan H
Pogosyan A
Fischer P
Carron R
Welter ML
Karachi C
Vandenberghe W
Nuttin B
Witjas T
Régis J
Azulay JP
Eusebio A
Brown P

Beta burst coupling across the motor circuit in Parkinson's disease.

2018. Neurobiol. Dis., 117(Sept):217-225.
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PMC6054304
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1.23 MB
Unit Publication
Herz DM
Little S
Pedrosa D
Tinkhauser G
Cheeran B
Foltynie T
Bogacz R
Brown P

Mechanisms Underlying Decision-Making as Revealed by Deep-Brain Stimulation in Patients with Parkinson's Disease.

2018. Curr. Biol., 28(8):1169-1178.e6.
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PMC5912902
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2.66 MB
Unit Publication
Tinkhauser G
Pogosyan A
Debove I
Nowacki A
Shah SA
Seidel K
Tan H
Brittain JS
Petermann K
di Biase L
Oertel M
Pollo C
Brown P
Schuepbach M

Directional local field potentials: A tool to optimize deep brain stimulation.

2018.Mov. Disord., 33(1):159-164.
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PMC5768242
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573.26 KB

2017

Unit Publication
Tinkhauser G
Brown P
Pogosyan A
Schuepbach M
Pollo C
Debove I

Patent Application: Method and system for optimisation of DBS programming

2017. WO/2017/158067
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810.08 KB
Unit Publication
Tinkhauser G
Pogosyan A
Tan H
Herz DM
Kühn AA
Brown P

Beta burst dynamics in Parkinson's disease OFF and ON dopaminergic medication.

2017. Brain, 140(11):2968-2981.
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PMC5667742
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998.05 KB
Unit Publication
Meidahl AC
Tinkhauser G
Herz DM
Cagnan H
Debarros J
Brown P

Adaptive Deep Brain Stimulation for Movement Disorders: The Long Road to Clinical Therapy.

2017.Mov. Disord., 32(6):810-819.

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PMC5482397
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647.98 KB
Unit Publication
Tinkhauser G
Pogosyan A
Little S
Beudel M
Herz DM
Tan H
Brown P

The modulatory effect of adaptive deep brain stimulation on beta bursts in Parkinson's disease.

2017. Brain, 140(4):1053-1067.
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PMC5382944
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928.26 KB